---
canonical: "https://www.softatlas.io/schrodinger/products/fep"
name: "FEP+"
provider: "Schrödinger"
category: "Industry Software / Life Sciences & R&D / AI Drug Discovery"
review_count: 0
format: "CORE_PRODUCT"
ai_powered: false
website: "https://www.schrodinger.com/platform/products/fep/"
updated: "2026-11-02"
---

# FEP+

By [Schrödinger](/schrodinger.md)

Free energy perturbation software that predicts protein-ligand binding affinity and other properties with physics-based calculations to prioritize compounds before synthesis.

## Features
- Predict relative binding affinity of compounds
- Calculate absolute binding free energies
- Predict selectivity across protein targets
- Estimate solubility from free energy calculations
- Prioritize compounds before synthesis
- Run calculations on GPU clusters and cloud

## Built for
OPERATIONS

Source: https://www.softatlas.io/schrodinger/products/fep